IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells, and has been shown to stimulate release of TNF-α and IL-1β from cells of the monocyte lineage. Recombinant Human IL-17B is a 36.6 kDa non-disulfide-linked homodimer of two 161 amino acid polypeptide chains.
- Species: Human
- Expression: E. coli Cell Expressed
- Purity: ≥98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 36.6 kDa
- Formulation: 1x PBS, pH 7.5
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Determined by its ability to induce IL-8 production in human PBMCs using a concentration range of 10.0-100.0 ng/ml. Results may vary with PBMC donors.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.