Products : Recombinant Human PDGFbb
Recombinant Human PDGFbb (Platelet-Derived Growth Factor bb)
- Animal-derived product free
- Lyophilized and Carrier Free (CF)
- High Stability
Xeno-free Recombinant Human PDGFbbHuXp is a growth factor that promotes blood vessel formation, mitogenesis, chemotaxis, etc. The PDGF family members (four homodimers and one heterodimer) are secreted, disulfide-linked dimeric glycoproteins that regulate their cellular functions through interaction with PDGFR ( and ) receptors. PDGFbb is synthesized, stored, and released by alpha granules of platelets. It is also known as PDGF-2, becaplermin, or GDGF. Dysregulation in PDGF signaling has been shown to be associated with tumorigenesis and progression of cancer. Recombinant PDGFbb is used in treatment of chronic ulcers and to speed healing in surgical procedures.
- Species: Human
- Expression: HEK293 Cell Expressed
- Activity: Typically ≤ 3 ng/mL EC50
- Purity: >95%
- Endotoxin: <1 EU/μg
- Molecular Mass: 29 to 32 kDa, homodimer, glycosylated
- Formulation: 50mM Acetate pH 3.5 + 500mM NaCl
The protein was resolved by SDS-polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
The activity was determined by the dose- dependent stimulation of the proliferation of 3T3 cells.
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 10 mM HOAc containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Synonyms: Platelet-Derived Growth Factor-BB, Glioma-derived growth factor (GDGF), Osteosarcoma-derived Growth Factor (ODGF) Platelet-Derived Growth FactorAA, Platelet-Derived Growth Factor AA,