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Native Glycosylation Is Important For Biological Function and Activity of Recombinant Human Proteins
Summary
Recombinant human cytokines are commercially available from bacterial, eukaryotic, and mammalian cell expression systems (E. coli, SF9, CHO), however human cell-expressed (HEK293) glycoproteins offer the distinct advantage of native human glycosylation. In this White Paper, several examples illustrating the importance of correct glycosylation in recombinant human cytokine activity, stability and half-life, are provided for cytokines widely used in stem cell research.