Products > Product Cytokines > IL-17 (IL-17A)

IL-17 (IL-17A)  (Interleukin 17A)

Product Description:

• Endotoxin-free
• Animal-derived product free
• Lyophilized and Carrier Free (CF)
• Available in Bulk

Xeno-free IL-17 (IL-17A) is expressed in human 293 cells as a homodimeric glycoprotein with an apparent molecular mass of 30 to 35 kDa. The IL-17 family is comprised of at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverage at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation.

Technical Specifications:

• Species: Human
• Expression: HEK293 Cell Expressed
• Activity: Typically ≤ 10 ng/mL EC50
• Purity: >95%
• Endotoxin: <1 EU/µg
• Molecular Mass: 30 to 35 kDa, homodimer
• Formulation: 10 mM Tris-HCl pH 7.4+ 150 mM NaCl

Purity Confirmation:

The protein was resolved by SDS- polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.

Activity Assay:

The activity was determined by the dose- dependent induction of IL-6 secretion from NHDF Adult fibroblasts

Reconstitution Buffer:

Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).

Synonyms: IL-17, CTLA-8 IL17A, IL 17A, IL 17, IL17, CTLA8, CTLA 8