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Recombinant Human Myostatin-Propeptide
Mature myostatin is obtained by proteolytic processing of a biologically-inactive precursor protein, which contains an N-terminal propeptide of 243 amino acid residues. Myostatin-Propeptide exhibits high binding affinity for myostatin, and has been shown to be a potent inhibitor of myostatin. Over-expression of myostatin-propeptide in mice resulted in large increases (up to 200%) in skeletal muscle mass, similar to those observed in myostatin knockout mice. Recombinant Human Myostatin-Propeptide is a 27.8 kDa protein consisting of 244 amino acid residues.
- Species: Human
- Expression: E. Coli Cell Expressed
- Activity: Typically 0.01-0.04 μg/mL ED50
- Purity: ≥98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 27.8 kDa
- Formulation: 20mm HCl
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Determined by its ability to neutralize the Myostatin inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.01–0.04 μg/ml in the presence of 50 ng/ml Myostatin.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.