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IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Human IL-5 is a 26.5 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.
- Species: Human
- Expression: E. coli Cell Expressed
- Activity: Typically ≤0.15 ng/mL ED50
- Purity: >98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 26.5 kDa, homodimeric
- Formulation: 20mM Sodium Phosphate, pH 7.5
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Determined by its ability to stimulate the proliferation of human TF-1 cells.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.