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IL-17E (Interleukin-17E)
Product Description:
IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulates secretion of IL-8, and induces activation of the transcription factor NF-κB in cells that express the IL-17BR receptor. Recombinant Human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 146 amino acid polypeptide chains.
Technical Specifications:
- Species: Human
- Expression: E. coli Cell Expressed
- Purity: ≥98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 33.8 kDa
- Country of Origin: USA
Purity Confirmation:
This was determined by SDS-PAGE gel and HPLC analysis.
Activity Assay:
Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10.0-100.0 ng/ml. Results will vary with PBMC donors.
AA Sequence:
MYSHWPSCCP | SKGQDTSEEL | LRWSTVPVPP |
LEPARPNRHP | ESCRASEDGP | LNSRAISPWR |
YELDRDLNRL | PQDLYHARCL | CPHCVSLQTG |
SHMDPRGNSE | LLYHNQTVFY | RRPCHGEKGT |
HKGYCLERRL | YRVSLACVCV | RPRVMG |
Reconstitution Buffer:
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Storage:
This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.
Cat #: | Size | Price |
HZ-7120 | 5 µg | $82 |
HZ-7121 | 25 µg | $201 |