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IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activities primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been linked to with rheumatoid arthritis, inflammatory bowel disease, and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues.
- Species: Human
- Expression: E. coli Cell Expressed
- Activity: Typically ≤0.5 ng/mL ED50
- Purity: >98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 12.9 kDa
- Formulation: 10 mM Sodium Phosphate, pH 8.5
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.