Relaxin 2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and ovaries during pregnancy. Of the three known relaxin genes, Relaxin 2 is the only relaxin known to circulate in the blood. Relaxin 2 binds specifically to the LGR7 and LGR8 receptors, previously identified as “orphan” G protein-coupled receptors. Signaling by Relaxin 2 through its target receptors enhances the growth of pubic ligaments, and the ripening of the cervix during birth. Recombinant Human Relaxin 2 is a non-glycosylated, 6.0 kDa, disulfide-linked, heterodimeric protein consisting of a 24 amino acid A-chain, and a 29 amino acid B-chain.
- Species: Human
- Expression: E. coli Cell Expressed
- Purity: ≥98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 6.0 kDa
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at-20°C to -80°C.