IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.
- Species: Human
- Expression: E. coli Cell Expressed
- Activity: Typically ≤2.0 ng/mL ED50
- Purity: >98%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 19.3 kDa
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Determined by the dose-dependent stimulation of the proliferation of murine T11 cells.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.