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IL-11 (Interleukin-11)

Product Description:

IL-11 is a multifunctional cytokine produced by stromal cells, such as fibroblasts, epithelial cells and osteoclasts. It is expressed in a wide variety of tissues, including thymus, lung, bone, connective tissue and central nervous system. IL-11 plays an important regulatory role in hematopoiesis by stimulating growth of myeloid, erythroid and megakaryocyte progenitor cells. It also regulates bone metabolism, inhibits production of proinflammatory cytokines, and protects against gastromucosal injury. Recombinant Human IL-11 is a 19.3 kDa protein consisting of 179 amino acid residues.

Technical Specifications:

  • Species: Human
  • Expression: E. coli Cell Expressed
  • Activity: Typically ≤2.0 ng/mL ED50
  • Purity: >98%
  • Endotoxin: <1.0 EU/μg
  • Molecular Mass: 19.3 kDa
  • Country of Origin: USA

Purity Confirmation:

This was determined by SDS-PAGE gel and HPLC analysis.

Activity Assay:

Determined by the dose-dependent stimulation of the proliferation of murine T11 cells.

AA Sequence:

SAKELRCQCI KTYSKPFHPK FIKELRVIES
GPHCANTEII VKLSDGRELC LDPKENWVQR
VVEKFLKRAE NS

Reconstitution Buffer:

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.

Storage:

This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

Cat #: Size Price
HZ-7048 2 µg $82
HZ-7049 10 µg $201
HZ-7050 100 µg $1,071
HZ-7052 500 µg $3,214
HZ-7053 1000 µg $5,356

XKine™ proteins are expressed in several expression systems

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