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IFN gamma (Immune Interferon gamma)

Product Description:

Interferon gamma (IFN-γ/IFNG) is a dimerized soluble cytokine that is the only member of the type II class of interferon. This interferon was originally called macrophage-activating factor, a term now used to describe a larger family of proteins to which IFN gamma belongs. IFN gamma has been used in a wide variety of clinical indications. Interferon gamma is a central regulator of the immune response and signals via the Janus Activated Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT) pathway. Interferon gamma has broader roles in activation of innate and adaptive immune responses to viruses and tumors, in part through upregulating transcription of genes involved in cell cycle regulation, apoptosis, and antigen processing/presentation. Despite this, rodent and human trophoblast cells show dampened responses to IFN gamma that reflect the resistance of these cells to IFNG-mediated activation of major histocompatibility complex (MHC) class II transplantation antigen expression.

Technical Specifications:

  • Species: Human
  • Expression: HEK293 Cell Expressed
  • Activity: Typically <0.05 ng/mL ED50
  • Purity: >95%
  • Endotoxin: <1.0 EU/μg
  • Molecular Mass: 16.8 kDa
  • Formulation: PBS, pH 7.4
  • Country of Origin: USA

Purity Confirmation:

This was determined by SDS-PAGE.

Activity Assay:

Determined by a cytotoxicity assay using HT-29 cells.

Reconstitution Buffer:

See Certificate of Analysis for reconstitution instructions and specific concentrations.

Storage:

Lyophilized Protein should be stored at -20° or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20° or -70°. Avoid repeated freeze-thaw cycles.

Cat #: Size Price
HZ-7223 100 µg $246
HZ-7224 1000 µg $1,492

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