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IFN beta (Immune Interferon beta)

Product Description:

Proteins of this family play an important role in inducing non-specific resistance against a broad range of viral infections. They also affect cell proliferation and modulate immune responses. Produced by peripheral blood leukocytes and lymphoblastoid cells, IFN alpha is an acid-stable molecule that signals through IFN-α/βR, which is also used by IFN beta. Both IFNs have similar anti-viral activity and regulate expression of MHC class I antigens. IFN alpha contains four highly conserved cysteine residues that form two disulfide bonds, one of which is necessary for biological activity.

Technical Specifications:

  • Species: Human
  • Expression: CHO Cell Expressed
    • Activity: Assay 1: Typically 20-30 ng/ml ED50
    • Assay 2: Typically ≤ 0.1 ng/ml
  • Purity: ≥95%
  • Endotoxin: <1.0 EU/μg
  • Molecular Mass: 22.3 kDa
  • Formulation: 10 mM Sodium Citrate, 100 mM Sodium Chloride + 10 mM Sucrose
  • Country of Origin: USA

Purity Confirmation:

This was determined by SDS-PAGE gel and HPLC analysis.

Activity Assay:

Assay#1: Determined by its ability to induce apoptosis in HeLa cells.

Assay#2: Determined by a cytotoxicity assay using human TF-1 cells.

AA Sequence:

MSYNLLGFLQ RSSNFQCQKL LWQLNGRLEY
CLKDRMNFDI PEEIKQLQQF QKEDAALTIY
EMLQNIFAIF RQDSSSTGWN ETIVENLLAN
VYHQINHLKT VLEEKLEKED FTRGKLMSSL
HLKRYYGRIL HYLKAKEYSH CAWTIVRVEI
LRNFYFINRL TGYLRN

Reconstitution Buffer:

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 1.0 mg/ml. Do not vortex.

Storage:

This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.

Cat #: Size Price
HZ-7207 5 µg $82
HZ-7208 20 µg $201

XKine™ proteins are expressed in several expression systems

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