BMP-10 (Bone Morphogenetic Protein-10)
Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation. It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes. BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.
- Species: Human
- Expression: HEK293 Cell Expressed
- Activity: Typically 4.0-6.0 ng/ml ED50
- Purity: ≥95%
- Endotoxin: <1.0 EU/μg
- Molecular Mass: 24.4 kDa
- Formulation: 10mM Sodium Citrate, pH 2.7 + 75mM NaC
- Country of Origin: USA
This was determined by SDS-PAGE gel and HPLC analysis.
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% HSA) and store in working aliquots at -20°C to -80°C.