Pleiotrophin (PTN) (Recombinant Human)
- Animal-derived product free
- Available in Bulk
- Expressed as a monomer
PTN is a member of a family of heparin-binding proteins that share sequence, structural, and functional similarity. Other members of this family include midkine (MK), and chicken retinoic acidinduced heparin-binding protein (RI-HB), an avian homologue of MK. The expression of all these cytokines is restricted and highly regulated during development.
Xeno-free HumanKine® Pleiotrophin is expressed in Human 293 cells as a secreted unglycosylated monomer.
- Species: Human
- Expression: HEK293 Cell Expressed
- Activity: N/A
- Purity: >95%
- Endotoxin: <1 EU/μg
- Molecular Mass: 18 kDa, monomer, reducing conditions, non-glycosylated
- Formulation: 1x PBS
The protein was resolved by SDS-polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
HumanZyme provides no lot specific activity data.
Activity is typically measured by enhancement of neurite outgrowth of E16-E18 rat embryonic cerebral cortical neurons (Muramatsu, H. and T. Muramatsu, 1991, Biochem. Biophys. Res. Commu. 177:652).
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Synonyms: Pleiotrophin, Heparin Affin Regulatory Protein (HARP), Heparin-binding growth factor-8(HBGF-8), Osteoblast-Specific Factor-1 (OSF-1) Heparin-binding growth factor8(HBGF8), Heparin-binding growth factor 8(HBGF 8), Osteoblast-Specific Factor1 (OSF1), Osteoblast-Specific Factor 1 (OSF 1)