IL-17F (Interleukin 17 F)
- Animal-derived product free
- Lyophilized and Carrier Free (CF)
- Authentic Glycosylation
Xeno-free IL-17F is a homodimeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, which contributes to stability in cell growth media and other applications. IL-17 is commonly associated with allergic responses. IL-17 induces the production of many other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1beta, TGF beta, and TNF alpha), chemokines (including IL-8, GRO alpha, and MCP-1), and prostaglandins (e.g., PGE2) from many cell types (fibroblasts, endothelial cell, epithelial cells, keratinocytes, and macrophages). The release of cytokines causes many functions, such as airway remodeling, a characteristic of IL-17 responses.
- Species: Human
- Expression: HEK293 Cell Expressed
- Activity: Typically ≤ 10 ng/mL EC50
- Purity: >95%
- Endotoxin: <1 EU/µg
- Molecular Mass: 38 kDa, homodimer, glycosylated
- Formulation: 1x PBS
The protein was resolved by SDS- polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
The activity was determined by the dose- dependent induction of IL-6 secretion from NHDF Adult fibroblasts.
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile 1xPBS containing 0.1% endotoxin-free recombinant human serum albumin (HSA).
Synonyms: IL 17F, IL17F