IFN beta (Interferon beta)
- Animal-derived product free
- High Activity
- Lyophilized and Carrier Free (CF)
Xeno-free IFN betaHuXp (IFN beta 1/ IFN beta 1a), is a member of type I family of interferons. It binds to a heterodimeric receptor, known as the IFNα/β receptor (IFNAR) resulting in activation of a number of Jak/ STAT proteins. Activation of this signaling pathway results in activation of genes that inhibit viral infection and regulate MHC class I antigens. It is primarily produced by fibroblasts and monocytes. In addition to inhibiting viral infection, IFN beta is also involved in regulating and activating immune response against bacteria, parasite and tumor cells. Multiple sclerosis is characterized by a deficiency of IFN beta 1. An injectable form of IFN beta 1 is used for MS treatment.
- Species: Human
- Expression: HEK293 Cell Expressed
- Activity: Typically ≤ 0.1 ng/mL EC50
- Purity: >95%
- Endotoxin: <1 EU/μg
- Molecular Mass: 18 to 22 kDa, glycosylated
- Formulation: Sodium Acetate pH 4.8 + 150mM NaCl + CHAPS
The protein was resolved by SDS-polyacrylamide gel electrophoresis and the gel was stained with Coomassie blue.
The activity was determined by dose dependent inhibition of proliferation of TF-1 cells1.
Briefly centrifuge the vial before opening. It is recommended to reconstitute the protein in sterile water.